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Linking membrane microstructure to performance 

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Most commercial membranes are fabricated using the phase inversion (PI) or interfacial polymerization (IP) processes. Both processes are limited by random fluctuations that form pores of unpredicted and unspecified sizes. Our approach is to discard PI and IP by developing pore structures by design using in vitro evolution.  To do this we need a fluid mechanics and intermolecular forces tool that can evaluate the selectivity of different proposed structures 'in silico'. We plan to test these new structures computationally and experimentally so as to achieve optimal performance. We will also fabricate and evaluate a new class of membranes based on assembly of microspheres. 

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Karla, S., Sorci, M., Moussa, B., Banik, R., Petersen, P.B., Plawsky, J. and Belfort, G., 2025. Hydrogen bonds and electrostatics drive adhesion of polar proteins to hydrophilized polymer membranes. Journal of Colloid and Interface Science, p.138530.

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Sorci et al., (2020) Linking Microstructure of Membranes and Performance, Journal of Membrane Science, 594, 117419

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